General Information

  • ID:  hor003246
  • Uniprot ID:  NA
  • Protein name:  Alpha-MSH (oxidized)
  • Gene name:  NA
  • Organism:  Mus musculus
  • Family:  Opioid neuropeptide precursor family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  SYSEHFRWGKPV
  • Length:  12
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T4 Glutamicacid oxidation;T12 Valine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor003246_AF2.pdbhor003246_ESM.pdb

Physical Information

Mass: 168902 Formula: C70H97N19O18
Absent amino acids: ACDILMNQT Common amino acids: S
pI: 9.3 Basic residues: 3
Polar residues: 4 Hydrophobic residues: 3
Hydrophobicity: -115.83 Boman Index: -2859
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 24.17
Instability Index: 5207.5 Extinction Coefficient cystines: 6990
Absorbance 280nm: 635.45

Literature

  • PubMed ID:  16903874
  • Title:  The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study.